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Hypercalciuria may be related to problems in the digestive tract that lead to increased calcium absorption, or dysfunctional renal calcium handling, but often no underlying cause is identified (Aliotta 2015)

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San Francisco: University of California

In addition, AS-IV has been found to restore the expression of p62, a sortilin protein, by reducing the levels of cystatin-C (Cyt-C) and poly (ADP-ribose) polymerase (PARP), thus correcting the autophagy imbalance in cardiomyocytes caused by DOX (Luo et al., 2021b)

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Another study (107) showed that GE induced apoptosis in FLSs of AIA rats by regulating the expression of apoptosis-related genes and inhibiting the activation of ERK signals